The study of Estrogen Receptor Expression in Breast Cancer in the Oncology Center of Imam Hussein Hospital in Karbala

Abstract

The most prevalent malignancy in women worldwide, and one of the main reasons why women die from cancer, is breast cancer (BC). Estrogen receptors, which are known to stimulate tumor cell growth and proliferation, are biologically expressed in the tumors of most women with BC. The study results show the relationship of receptor (ER) expression with age group. This study showed that the highest expression of ER was in the third group, with 36.36%, compared to the other groups. There was also a high incidence of estrogen receptor (ER) expression in the invasive ductal carcinoma, invasive lobular carcinoma, and LABC stages of breast cancer; the score 3 (positive expression) group had the highest expression of ER (32.72%, 58.33%, and 56.25%, respectively) compared to the other groups. Furthermore, there was a high incidence of estrogen receptor (ER) expression in the metastatic and multifocal breast cancer stages; the negative expression (score 1) group had the highest expression of ER (75%) compared to the other groups. Statistical analysis revealed that a higher incidence of non-expression (negative) count in the thrid age group was about 12 (30%) patients compared to the other groups, while negative expression 1 was the highest incidence in the third and fifth groups, about 10 (45.45%) patients in each group compared to the other groups, while low positive expression was the highest incidence in the third group, about 24 (57.14%) patients compared to the other groups. Also, the positive expression was the highest rate in the third group, about 26 (44.82%) patients, compared to the other groups.