Hematological Disorders of Systemic Lupus Erythematosus: A Cross-Sectional Study

Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disease with unknown etiology. It involves multiple organs and presents as varying clinical and hematological manifestations. Investigations are very important to diagnose SLE, including CBC, ESR. Limited data were reported for the frequency of SLE in Libya. A cross-sectional study aims to assess the prevalence of SLE in Tripoli, Libya. A total of 140 participants, including both genders and aged between 17 and 59 years. Diagnostic Tests and Blood Screening include a complete blood picture and Erythrocyte Sedimentation Rate (ESR). Gender-wise distribution was 93.52% females and 6.48% males. The percentage of SLE was highest in the age group 27 – 36 years (34.26%). The mean ESR was significantly increased in SLE patients compared to the control. While the mean Hgb was decreased compared to the control. The relationship between monocytes and neutrophils in two groups of SLE was also investigated by comparing SLE patients with the control group. The mean Monocytes and neutrophils were significantly increased in SLE patients compared to the control. There are no significant differences in Lymphocytes between SLE patients and control subjects. SLE is a chronic disease that is affected by multiple factors such as age, gender. Alterations in blood tests in SLE patients are a key point in disease diagnosis.